研究成果・広報活動
研究成果一覧
学術論文 2018年
Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.
Cole JW, Xu H, Ryan K, et al. Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke. PLoS One. 2018;13(11):e0206554. doi: 10.1371/journal.pone.0206554.
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
Feitosa MF, Kraja AT, Chasman DI, et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One. 2018;13(6):e0198166. doi: 10.1371/journal.pone.0198166.
Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians.
Han B, Akiyama M, Kim KK, et al. Amino acid position 37 of HLA-DRbeta1 affects susceptibility to Crohn's disease in Asians. Hum Mol Genet. 2018;27(22):3901-3910. doi: 10.1093/hmg/ddy285.
Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study.
Hishida A, Nakatochi M, Akiyama M, et al. Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study. Am J Nephrol. 2018;47(5):304-316. doi: 10.1159/000488946.
Elucidating the genetic architecture of reproductive ageing in the Japanese population.
Horikoshi M, Day FR, Akiyama M, et al. Elucidating the genetic architecture of reproductive ageing in the Japanese population. Nat Commun. 2018;9(1):1977-018-04398-z. doi: 10.1038/s41467-018-04398-z.
Re-evaluating classical body type theories: genetic correlation between psychiatric disorders and body mass index.
Ikeda M, Tanaka S, Saito T, et al. Re-evaluating classical body type theories: genetic correlation between psychiatric disorders and body mass index. Psychol Med. 2018;48(10):1745-1748. doi: 10.1017/S0033291718000685.
Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.
Kabe Y, Suematsu M, Sakamoto S, et al. Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human sera. Clin Chem. 2018;64(10):1463-1473. doi: 10.1373/clinchem.2018.291963.
Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.
Khanshour AM, Kou I, Fan Y, et al. Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci. Hum Mol Genet. 2018;27(22):3986-3998. doi: 10.1093/hmg/ddy306.
Identification of LEF1 as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age.
Kim HJ, Yun SW, Yu JJ, et al. Identification of LEF1 as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age. Genomics Inform. 2018;16(2):36-41. doi: 10.5808/GI.2018.16.2.36.
Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis.
Kochi Y, Kamatani Y, Kondo Y, et al. Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis. Ann Rheum Dis. 2018;77(4):602-611. doi: 10.1136/annrheumdis-2017-212149.
A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis.
Kou I, Watanabe K, Takahashi Y, et al. A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis. Sci Rep. 2018;8(1):11575-018-29011-7. doi: 10.1038/s41598-018-29011-7.
Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls.
Momozawa Y, Iwasaki Y, Parsons MT, et al. Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls. Nat Commun. 2018;9(1):4083-018-06581-8. doi: 10.1038/s41467-018-06581-8.
Association of HLA-A*31:01 Screening With the Incidence of Carbamazepine-Induced Cutaneous Adverse Reactions in a Japanese Population.
Mushiroda T, Takahashi Y, Onuma T, et al. Association of HLA-A*31:01 Screening With the Incidence of Carbamazepine-Induced Cutaneous Adverse Reactions in a Japanese Population. JAMA Neurol. 2018;75(7):842-849. doi: 10.1001/jamaneurol.2018.0278 .
Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese.
Okada Y, Momozawa Y, Sakaue S, et al. Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese. Nat Commun. 2018;9(1):1631-018-03274-0. doi: 10.1038/s41467-018-03274-0.
Multi-ethnic genome-wide association study for atrial fibrillation.
Roselli C, Chaffin MD, Weng LC, et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018;50(9):1225-1233. doi: 10.1038/s41588-018-0133-9.
Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity.
Sakaue S, Hirata J, Maeda Y, et al. Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity. Nucleic Acids Res. 2018;46(22):11898-11909. doi: 10.1093/nar/gky1066.
A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
Taira M, Imamura M, Takahashi A, et al. A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. PLoS One. 2018;13(12):e0208654. doi: 10.1371/journal.pone.0208654.
Blood lipid-related low-frequency variants in LDLR and PCSK9 are associated with onset age and risk of myocardial infarction in Japanese.
Tajima T, Morita H, Ito K, et al. Blood lipid-related low-frequency variants in LDLR and PCSK9 are associated with onset age and risk of myocardial infarction in Japanese. Sci Rep. 2018;8(1):8107-018-26453-x. doi: 10.1038/s41598-018-26453-x.
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
Takeuchi F, Akiyama M, Matoba N, et al. Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nat Commun. 2018;9(1):5052-018-07345-0. doi: 10.1038/s41467-018-07345-0.
Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.
Tanikawa C, Kamatani Y, Toyoshima O, et al. Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21. Cancer Sci. 2018;109(12):4015-4024. doi: 10.1111/cas.13815.
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
Teumer A, Chaker L, Groeneweg S, et al. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. Nat Commun. 2018;9(1):4455-018-06356-1. doi: 10.1038/s41467-018-06356-1.
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
van Zuydam NR, Ahlqvist E, Sandholm N, et al. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes. 2018;67(7):1414-1427. doi: 10.2337/db17-0914.
Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.
Yamaguchi-Kabata Y, Morihara T, Ohara T, et al. Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease. Hum Genet. 2018;137(6-7):521-533. doi: 10.1007/s00439-018-1906-z.
Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1.
Yodsurang V, Tang Y, Takahashi Y, et al. Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1. PLoS One. 2018;13(12):e0209096. doi: 10.1371/journal.pone.0209096.
Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density.
Zhou X, Cheung CL, Karasugi T, et al. Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density. Front Genet. 2018;9:267. doi: 10.3389/fgene.2018.00267.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik *, Ganesh Chauhan *, Matthew Traylor *, Muralidharan Sargurupremraj *, Yukinori Okada *, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Jr. , Adam S Butterworth, Caty Carrera, Cara L Carty, Daniel I Chasman, Wei-Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Susan R Heckbert, Elizabeth G Holliday, George Howard, Fang-Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez-Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin-Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei-Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O'Donnell, Bruce M Psaty, Sara L Pulit, Kristiina Rannikmäe, Alexander P Reiner, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Paul M Ridker, Natalia S Rost, Peter M Rothwell, Jerome I Rotter, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt , Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil-Smoller, James G Wilson, Kerri L Wiggins, Qiong Yang, Salim Yusuf, AFGen consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT consortium, STARNET, Joshua C Bis, Tomi Pastinen, Arno Ruusalepp, Eric E Schadt, Simon Koplev, Johan LM Björkegren, Veronica Codoni, Mete Civelek, Nicholas L Smith, David A Trégouët, Ingrid E Christophersen, Carolina Roselli, Steven A Lubitz, Patrick T Ellinor, E Shyong Tai, Jaspal S Kooner, Norihiro Kato, Jiang He, Pim van der Harst, Paul Elliott, John C Chambers, Fumihiko Takeuchi, Andrew D Johnson, BioBank Japan Cooperative Hospital Group, COMPASS consortium, EPIC-CVD consortium, EPIC-InterAct consortium, International Stroke Genetics Consortium (ISGC), METASTROKE Consortium, Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGASTROKE Consortium, Dharambir K Sanghera DK, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez-Cadenas, W T Longstreth, Jr, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen , Kari Stefansson **, Bradford B Worrall **, Steven J Kittner **, Sudha Seshadri **, Myriam Fornage **, Hugh S Markus **, Joanna MM Howson **, Yoichiro Kamatani **, Stephanie Debette **§ and Martin Dichgans **§,
Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma
Yukihiro Shiga*, Masato Akiyama*, Koji M. Nishiguchi, Kota Sato, Nobuhiro Shimozawa, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane, Isao Oze, Haruo Mikami, Mariko Naito, Kenji Wakai, Munemitsu Yoshikawa, Masahiro Miyake, Kenji Yamashiro, Japan Glaucoma Society Omics Group: Kenji Kashiwagi, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Makoto Aihara, Makoto Araie, Tetsuya Yamamoto, Yoshiaki Kiuchi, Makoto Nakamura, Yasuhiro Ikeda, Koh-Hei Sonoda, Tatsuro Ishibashi, Koji Nitta, Aiko Iwase, Shiroaki Shirato, Yoshitaka Oka, Mamoru Satoh, Makoto Sasaki, Nobuo Fuse, Yoichi Suzuki, Ching-Yu Cheng, Chiea Chuen Khor, Mani Baskaran, Shamira Perera, Tin Aung, Eranga N. Vithana, Jessica N. Cooke Bailey, Jae H.Kang, Louis R. Pasquale, Jonathan L. Haines, NEIGHBORHOOD consortium, Janey L. Wiggs, Kathryn P. Burdon, Puya Gharahkhani, Alex W. Hewitt, David A. Mackey, Stuart MacGregor, Jamie E. Craig, R. Rand Allingham, Micheal Hauser, Adeyinka Ashaye, Donald L. Budenz, Stephan Akafo, Susan E.I. Williams, Yoichiro Kamatani, Toru Nakazawa, Michiaki Kubo
本人通知制度の実態と住民票を用いた予後調査への影響の検討
永井 亜貴子, 武藤 香織, 井上 悠輔. 本人通知制度の実態と住民票を用いた予後調査への影響の検討. 日本公衆衛生雑誌. 2018;65(5):223-232. https://ci.nii.ac.jp/naid/130007377644/. doi: 10.11236/jph.65.5_223.
https://www.jstage.jst.go.jp/article/jph/65/5/65_17-071/_pdf/-char/ja
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