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Initiatives & Research
Machine learning reveals heterogeneous associations between environmental factors and cardiometabolic diseases across polygenic risk scores
Tatsuhiko Naito, Kosuke Inoue, Shinichi Namba, et al.
Large-scale cross-trait genetic analysis highlights shared genetic backgrounds of autoimmune diseases
Yuji Yamamoto, Yuya Shirai, Ryuya Edahiro, et al.
Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome‐Wide Association and Mendelian Randomization Study
Kosuke Inoue, Tatsuhiko Naito, Ryosuke Fuji, et al.
Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults
Alfred Pozarickij, Wei Gan, Kuang Lin, et al.
Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues
Yoshihiko Tomofuji, Ryuya Edahiro, Kyuto Sonehara, et al.
Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals
Masato Akiyama, Gen Tamiya, Kohta Fujiwara, et al.
Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss
Kyuto Sonehara, Yoshitaka Yano, Tatsuhiko Naito, et al.
Genome-wide association study on meningioma risk in Japan: a multicenter prospective study
Shuhei Yamada, Toru Umehara, Kyuto Sonehara, et al.
PMID: 39002029
Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population
Ryosuke Fujii, Asahi Hishida, Masahiro Nakatochi, et al.
Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Katherine A. Kentistou, Lena R. Kaisinger, Stasa Stankovic, et al.
Genome-Wide Association Study with Three Control Cohorts of Japanese Patients with Esotropia and Exotropia of Comitant Strabismus and Idiopathic Superior Oblique Muscle Palsy
Toshihiko Matsuo, Ichiro Hamasaki, Yoichiro Kamatani, et al.
KEAP1–NRF2 system regulates age-related spermatogenesis dysfunction
Sohei Kuribayashi, Shinichiro Fukuhara, Hiroaki Kitakaze, et al.
Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population
Masato Takase, Naoki Nakaya, Tomohiro Nakamura, et al.
Protocol for genome-wide association study of human blood metabolites
Takeshi Iwasaki, Yoichiro Kamatani, Kazuhiro Sonomura, et al.
RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction
Keiko Hikino, Satoshi Koyama, Kaoru Ito, et al.
A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk
Bradley Jermy, Kristi Läll, Brooke N. Wolford, et al.
Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease
Rainer Malik, Nathalie Beaufort, Jiang Li, et al.
Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses
Takafumi Ojima, Shinichi Namba, Ken Suzuki, et al.
Genetic variants for head size share genes and pathways with cancer
Maria J. Knol, Raymond A. Poot, Tavia E. Evans, et al.
Identification of an novel genetic variant associated with osteoporosis: insights from the Taiwan Biobank Study
Yi-Ching Liaw, Koichi Matsuda and Yung-Po Liaw.
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Zhishan Chen, Xingyi Guo, Ran Tao, et al.
Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions
Mark P. Purdue, Diptavo Dutta, Mitchell J. Machiela, et al.
Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing
Xiaoxi Liu, Satoshi Koyama, Kohei Tomizuka, et al.
Poor accuracy and sustainability of the first-step FIB4 EASL pathway for stratifying steatotic liver disease risk in the general population
Antonio De Vincentis, Federica Tavaglione, Shinichi Namba, et al.
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, et al.
Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation
Valeria Lo Faro, Arjun Bhattacharya, Wei Zhou, et al.
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, et al.
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
Rosalie B. T. M. Sterenborg, Inga Steinbrenner, Yong Li, et al.
Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people
Yuriko N. Koyanagi, Masahiro Nakatochi, Shinichi Namba, et al.
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
Markus Scholz, Katrin Horn, Janne Pott, et al.
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Xiangrui Meng, Georgina Navoly, Olga Giannakopoulou, et al.
Genetic risk score of cerebral infarction in atrial fibrillation genome-wide association study
Yusuke Ebana, Lian Liu, Kensuke Ihara, et al.
East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease
Yunye He, Masaru Koido, Yoichi Sutoh, et al.
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
Anqi Wang, Jiayi Shen, Alex A. Rodriguez, et al.
A large-scale microRNA transcriptome-wide association study identifies two susceptibility microRNAs, miR-1307-5p and miR-192-3p, for colorectal cancer risk
Zhishan Chen, Weiqiang Lin, Qiuyin Cai, et al.
Extracting immunological and clinical heterogeneity across autoimmune rheumatic diseases by cohort-wide immunophenotyping
Hiroaki Tanaka, Yukinori Okada, Shingo Nakayamada, et al.
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses
Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, et al.
Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology
Ying Wang, Masahiro Kanai, Taotao Tan, et al.
Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations
Xiaoxi Liu, Masatoshi Matsunami, Momoko Horikoshi, et al.
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, et al.
Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores
Adrian I. Campos, Shinichi Namba, Shu-Chin Lin, et al.
Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration
B. H. Scammell, C. Tchio, Y. Song, et al.
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
International League Against Epilepsy Consortium on Complex Epilepsies.
Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects
Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, et al.
ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk
Lenka Stolarova, Petra Kleiblova, Petra Zemankova, et al.
A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants
Jaeyong Choi, Sungjae Kim, Juhyun Kim, et al.
Contribution of an Asian-prevalent HLA haplotype to the risk of HBV-related hepatocellular carcinoma
Atsushi Kawamura, Koichi Matsuda, Yoshinori Murakami, et al.
Genome-wide Association Studies Categorized by Class of Antihypertensive Drugs Reveal Complex Pathogenesis of Hypertension with Drug Resistance
Keiko Yamazaki, Chikashi Terao, Atsushi Takahashi, et al.
Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study
Yoshinari Nakatsuka, Kimihiko Murase, Kazuhiro Sonomura, et al.
GWAS of Folate Metabolism with Gene-Environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese – the J-MICC Study
Mineko Tsukamoto, Asahi Hishida, Takashi Tamura, et al.
