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Initiatives & Research
Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses
Takafumi Ojima, Shinichi Namba, Ken Suzuki, et al.
Genetic variants for head size share genes and pathways with cancer
Maria J. Knol, Raymond A. Poot, Tavia E. Evans, et al.
Identification of an novel genetic variant associated with osteoporosis: insights from the Taiwan Biobank Study
Yi-Ching Liaw, Koichi Matsuda and Yung-Po Liaw.
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Zhishan Chen, Xingyi Guo, Ran Tao, et al.
Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions
Mark P. Purdue, Diptavo Dutta, Mitchell J. Machiela, et al.
Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing
Xiaoxi Liu, Satoshi Koyama, Kohei Tomizuka, et al.
Poor accuracy and sustainability of the first-step FIB4 EASL pathway for stratifying steatotic liver disease risk in the general population
Antonio De Vincentis, Federica Tavaglione, Shinichi Namba, et al.
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, et al.
Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation
Valeria Lo Faro, Arjun Bhattacharya, Wei Zhou, et al.
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, et al.
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
Rosalie B. T. M. Sterenborg, Inga Steinbrenner, Yong Li, et al.
Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people
Yuriko N. Koyanagi, Masahiro Nakatochi, Shinichi Namba, et al.
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
Markus Scholz, Katrin Horn, Janne Pott, et al.
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Xiangrui Meng, Georgina Navoly, Olga Giannakopoulou, et al.
Genetic risk score of cerebral infarction in atrial fibrillation genome-wide association study
Yusuke Ebana, Lian Liu, Kensuke Ihara, et al.
East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease
Yunye He, Masaru Koido, Yoichi Sutoh, et al.
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
Anqi Wang, Jiayi Shen, Alex A. Rodriguez, et al.
A large-scale microRNA transcriptome-wide association study identifies two susceptibility microRNAs, miR-1307-5p and miR-192-3p, for colorectal cancer risk
Zhishan Chen, Weiqiang Lin, Qiuyin Cai, et al.
Extracting immunological and clinical heterogeneity across autoimmune rheumatic diseases by cohort-wide immunophenotyping
Hiroaki Tanaka, Yukinori Okada, Shingo Nakayamada, et al.
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses
Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, et al.
Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology
Ying Wang, Masahiro Kanai, Taotao Tan, et al.
Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations
Xiaoxi Liu, Masatoshi Matsunami, Momoko Horikoshi, et al.
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, et al.
Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores
Adrian I. Campos, Shinichi Namba, Shu-Chin Lin, et al.
Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration
B. H. Scammell, C. Tchio, Y. Song, et al.
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
International League Against Epilepsy Consortium on Complex Epilepsies.
Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects
Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, et al.
ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk
Lenka Stolarova, Petra Kleiblova, Petra Zemankova, et al.
A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants
Jaeyong Choi, Sungjae Kim, Juhyun Kim, et al.
Contribution of an Asian-prevalent HLA haplotype to the risk of HBV-related hepatocellular carcinoma
Atsushi Kawamura, Koichi Matsuda, Yoshinori Murakami, et al.
Genome-wide Association Studies Categorized by Class of Antihypertensive Drugs Reveal Complex Pathogenesis of Hypertension with Drug Resistance
Keiko Yamazaki, Chikashi Terao, Atsushi Takahashi, et al.
Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study
Yoshinari Nakatsuka, Kimihiko Murase, Kazuhiro Sonomura, et al.
GWAS of Folate Metabolism with Gene-Environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese – the J-MICC Study
Mineko Tsukamoto, Asahi Hishida, Takashi Tamura, et al.
Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis
Yoshiyuki Akiyama, Kyuto Sonehara, Daichi Maeda, et al.
Genetic insights into ossification of the posterior longitudinal ligament of the spine
Yoshinao Koike, Masahiko Takahata, Masahiro Nakajima, et al.
Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis
Go Sato, Yuya Shirai, Shinichi Namba, et al.
Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study
Nao Otomo, Anas M. Khanshour, Masaru Koido, et al.
Detection of trait-associated structural variations using short-read sequencing
Shunichi Kosugi, Yoichiro Kamatani, Katsutoshi Harada, et al.
Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score
Yugo Morita, Yoichiro Kamatani, Hiromu Ito, et al.
Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning
Masaru Koido, Chung-Chau Hon, Satoshi Koyama, et al.
Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk
Shohei Kojima, Satoshi Koyama, Mirei Ka, et al.
Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study
Shogo Dofuku, Kyuto Sonehara, Satoru Miyawaki, et al.
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, et al.
Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation
Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, et al.
Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants
Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, et al.
Genetic Risk of Primary Aldosteronism and its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies
Tatsuhiko Naito, Kosuke Inoue, Kyuto Sonehara, et al.
Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population
Takuya Sakashita, Yasuyuki Nakamura, Yoichi Sutoh, et al.
Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, et al.
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity
Mark K. Bakker, Jos P. Kanning, Gad Abraham, et al.
Prediction Model with HLA-A*33:03 Reveals Number of Days to Develop Liver Cancer from Blood Test
Nao Nishida, Jun Ohashi, Goki Suda, et al.
