Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

Ying Wang, Shinichi Namba, Esteban Lopera, et al.

• PMID: 36777179

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

Yoshihiko Tomofuji, Ken Suzuki, Toshihiro Kishikawa, et al.

• PMID: 36624208

Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population

Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, et al.

• PMID: 36162535

Genetic footprints of assortative mating in the Japanese population

Kenichi Yamamoto, Kyuto Sonehara, Shinichi Namba, et al.

• PMID: 36138222

Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk

James Yarmolinsky, Christopher I. Amos, Rayjean J. Hung, et al.

• PMID: 35747941

Genetic diversity fuels gene discovery for tobacco and alcohol use

Gretchen R. B. Saunders, Xingyan Wang, Fang Chen, et al.

• PMID: 36477530

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Krishna G. Aragam, Tao Jiang, Anuj Goel, et al.

• PMID: 36474045

Genetic Architectures Underlie Onset Age of Atopic Dermatitis

Keiko Hikino, Nao Tanaka, Masaru Koido, et al.

• PMID: 35841947

Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians

Jie Ping, Yaohua Yang, Wanqing Wen, et al.

• PMID: 35765848

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Kazuyoshi Ishigaki, Saori Sakaue, Chikashi Terao, et al.

• PMID: 36333501

Stroke genetics informs drug discovery and risk prediction across ancestries

Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, et al.

• PMID: 36180795

Association between germline pathogenic variants in cancer-predisposing genes and lymphoma risk

Yoshiaki Usui, Yusuke Iwasaki, Keitaro Matsuo, et al.

• PMID: 36065483

Population-based Screening for Hereditary Colorectal Cancer Variants in Japan

Masashi Fujita, Xiaoxi Liu, Yusuke Iwasaki, et al.

• PMID: 33309985

DOCK2 is involved in the host genetics and biology of severe COVID-19

Ho Namkoong, Ryuya Edahiro, Tomomi Takano, et al.

• PMID: 35940203

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

Catherine Tcheandjieu, Xiang Zhu, Austin T. Hilliard, et al.

• PMID: 35915156

Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component

Yuya Shirai, Yoshimitsu Nakanishi, Akari Suzuki, et al.

• PMID: 35753705

Different risk genes contribute to clear cell and non-clear cell renal cell carcinoma in 1532 Japanese patients and 5996 controls

Yuya Sekine, Yusuke Iwasaki, Tomomi Aoi, et al.

• PMID: 35764097

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Thomas W. Winkler, Humaira Rasheed, Alexander Teumer, et al.

• PMID: 35697829

Genetic analysis of right heart structure and function in 40,000 people

James P. Pirruccello, Paolo Di Achille, Victor Nauffal, et al.

• PMID: 35697867

Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants

Yukihide Momozawa, Rumi Sasai, Yoshiaki Usui, et al.

• PMID: 35420638

Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk

Xiang Shu, Zhishan Chen, Jirong Long, et al.

• PMID: 35266989

Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study

Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, et al.

• PMID: 35609976

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Anubha Mahajan, Cassandra N. Spracklen, Weihua Zhang, et al.

• PMID: 35551307

A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study

Xiangfeng Lu, Zhongying Liu, Qingmei Cui, et al.

• PMID: 35195259

Editorial: Current Status and Future Challenges of Biobank Data Analysis

Tzu-Pin Lu, Yoichiro Kamatani, Gillian Belbin, et al.

• PMID: 35495141

Genome-wide risk prediction of common diseases across ancestries in one million people

Nina Mars, Sini Kerminen, Yen-Chen A. Feng, et al.

• PMID: 35591975

Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

Omer Weissbrod, Masahiro Kanai, Huwenbo Shi, et al.

• PMID: 35393596

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy, Antonio F. Pardiñas, Ting Qi, et al.

• PMID: 35396580

Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682

Adem Y. Dawed, Sook Wah Yee, Kaixin Zhou, et al.

• PMID: 35349657

Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus

Hiroyuki Suetsugu, Kwangwoo Kim, Takuaki Yamamoto, et al.

• PMID: 34850884

Federated analysis of BRCA1 and BRCA2 variation in a Japanese cohort

James Casaletto, Michael Parsons, Charles Markello, et al.

• PMID: 35373174

Whole exome analysis of patients in Japan with hearing loss reveals high heterogeneity among responsible and novel candidate genes

Hideki Mutai, Yukihide Momozawa, Yoichiro Kamatani, et al.

• PMID: 35248088

Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer

Keiko Hikino, Masaru Koido, Nao Otomo, et al.

• PMID: 34671089

A single-nucleotide-polymorphism in the 5′-flanking region of MSX1 gene as a predictive marker candidate for platinum-based therapy of esophageal carcinoma

Takahiro Mori, Kazuko Ueno, Katsushi Tokunaga, et al.

• PMID: 35251318

[Cohorts and Biobanks as Essential Resources for Cancer Research]

Yoshinori Murakami.

• PMID: 35249044

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease

Jie Zheng, Yuemiao Zhang, Humaira Rasheed, et al.

• PMID: 34999880

The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, et al.

• PMID: 34887591

Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome-wide association study

Zhanwei Wang, Anuradha S. Budhu, Yi Shen, et al.

• PMID: 34950780

A cross-population atlas of genetic associations for 220 human phenotypes

Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, et al.

• PMID: 34594039

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

Pik Fang Kho, Sally Mortlock, Endometrial Cancer Association Consortium, et al.

• PMID: 34268601

A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population

Yasuo Takahashi, Keiko Yamazaki, Yoichiro Kamatani, et al.

• PMID: 34593835

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects

Olusegun O. Onabajo, Fang Wang, Mei-Hsuan Lee, et al.

• PMID: 34497603

Genetic insights into biological mechanisms governing human ovarian ageing

Katherine S. Ruth, Felix R. Day, Jazib Hussain, et al.

• PMID: 34349265

All-cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort

Hiroshi Yokomichi, Mie Mochizuki, Makoto Hirata, et al.

• PMID: 33340268

Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias

Keiko Hikino, Masaru Koido, Kohei Tomizuka, et al.

• PMID: 34392144

Genetics of autosomal mosaic chromosomal alteration (mCA)

Xiaoxi Liu, Yoichiro Kamatani and Chikashi Terao.

• PMID: 34321609

Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis

Ryunosuke Saiki, Yukihide Momozawa, Yasuhito Nannya, et al.

• PMID: 34239136

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Seyedeh M. Zekavat, Shu-Hong Lin, Alexander G. Bick, et al.

• PMID: 34099924

Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

Qingbo S. Wang, David R. Kelley, Jacob Ulirsch, et al.

• PMID: 34099641

Cancer-associated miRNAs and their therapeutic potential

Jun Inoue and Johji Inazawa.

• PMID: 34088973