Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging

Takuro Kobayashi, Tsuyoshi Hachiya, Yan Lu, et al.

• PMID: 40730558

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Ryuya Edahiro, Go Sato, Tatsuhiko Naito, et al.

• PMID: 40721531

A POLR1D-regulating single-nucleotide polymorphism as a predictive marker candidate for platinum-based chemotherapy in gastrointestinal cancers

Takahiro Mori, Kazuko Ueno, Masao Nagasaki, et al.

• PMID: 40661991

Clinical Significance of TP53-Mutant Clonal Hematopoiesis Across Diseases

Yoshiaki Usui, Mikiko Endo, Yusuke Iwasaki, et al.

• PMID: 40525786

Genomic profiles of pathogenic and moderate-penetrance germline variants associated with risk of early-onset lung adenocarcinoma

Hourin Cho, Kouya Shiraishi, Kuniko Sunami, et al.

• PMID: 40516820

Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysis

Shu Yazaki, Megumi Hori, Hisaki Aiba, et al.

• PMID: 40403695

The contribution of gametic phase disequilibrium to the heritability of complex traits

Yuanxiang Zhang, Saori Sakaue, Sam Morris, et al.

• PMID: 40389611

Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases

Yuji Yamamoto, Yuya Shirai, Kyuto Sonehara, et al.

• PMID: 40295474

A genome-wide meta-analysis reveals shared and population-specific variants for allergic sensitization

Emiko Noguchi, Wataru Morii, Haruna Kitazawa, et al.

• PMID: 39644933

Recurrent Stroke Prediction by Applying a Stroke Polygenic Risk Score in the Japanese Population

Naoki Kojima, Masaru Koido, Yunye He, et al.

• PMID: 40135360

Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity

Kyuto Sonehara, Yoshifumi Uwamino, Ryunosuke Saiki, et al.

• PMID: 40043710

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases

Carolina Roselli, Ida Surakka, Morten S. Olesen, et al.

• PMID: 40050429

A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population

Noriko Ohyama, Masatoshi Matsunami, Minako Imamura, et al.

• PMID: 39987337

Mosaic loss of chromosome Y characterises late-onset rheumatoid arthritis and contrasting associations of polygenic risk score based on age at onset

Shunsuke Uchiyama, Yuki Ishikawa, Katsunori Ikari, et al.

• PMID: 39986957

Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder

Tomohiro Yata, Go Sato, Kotaro Ogawa, et al.

• PMID: 39986280

Genetic analysis of myeloid neoplasms with der(1;7)(q10;p10)

Rurika Okuda, Yotaro Ochi, Ryunosuke Saiki, et al.

PMID: 39715854

Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population

Jack Flanagan, Xiaoxi Liu, David Ortega-Reyes, et al.

• PMID: 39702642

Cancer and disease profiles for PTEN pathogenic variants in Japanese population

Yuki Kanazashi, Yoshiaki Usui, Yusuke Iwasaki, et al.

• PMID: 39663357

Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report

Batel Blechter, Chao Agnes Hsiung, Xiaoyu Wang, et al.

• PMID: 39581378

Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations

Kenichi Yamamoto, Shinichi Namba, Kyuto Sonehara, et al.

• PMID: 39532881

Genomic variants associated with age at diagnosis of childhood-onset type 1 diabetes

Pierre Bougnères, Sophie Le Fur, Yoichiro Kamatani, et al.

• PMID: 38982180

A genome-wide association analysis reveals new pathogenic pathways in gout

Tanya J. Major, Riku Takei, Hirotaka Matsuo, et al.

• PMID: 39406924

Inconsistent embryo selection across polygenic score methods

Shinichi Namba, Masato Akiyama, Haruka Hamanoue, et al.

• PMID: 39402258

Artificial intelligence in medical genomics

Yoichiro Kamatani and Tadashi Kaname.

• PMID: 39192016

Population-specific putative causal variants shape quantitative traits

Satoshi Koyama, Xiaoxi Liu, Yoshinao Koike, et al.

• PMID: 39363016

Genotype imputation methods for whole and complex genomic regions utilizing deep learning technology

Tatsuhiko Naito and Yukinori Okada.

• PMID: 38225263

Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance

Qingbo S. Wang, Takanori Hasegawa, Ho Namkoong, et al.

• PMID: 39317738

Genome-wide association studies for pelvic organ prolapse in the Japanese population

Masatoshi Matsunami, Minako Imamura, Asuka Ashikari, et al.

• PMID: 39349682

Machine learning reveals heterogeneous associations between environmental factors and cardiometabolic diseases across polygenic risk scores

Tatsuhiko Naito, Kosuke Inoue, Shinichi Namba, et al.

• PMID: 39304733

Large-scale cross-trait genetic analysis highlights shared genetic backgrounds of autoimmune diseases

Yuji Yamamoto, Yuya Shirai, Ryuya Edahiro, et al.

• PMID: 39171621

Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome‐Wide Association and Mendelian Randomization Study

Kosuke Inoue, Tatsuhiko Naito, Ryosuke Fuji, et al.

• PMID: 39101507

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

Alfred Pozarickij, Wei Gan, Kuang Lin, et al.

• PMID: 39048560

Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues

Yoshihiko Tomofuji, Ryuya Edahiro, Kyuto Sonehara, et al.

• PMID: 39084228

Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals

Masato Akiyama, Gen Tamiya, Kohta Fujiwara, et al.

• PMID: 39023470

Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss

Kyuto Sonehara, Yoshitaka Yano, Tatsuhiko Naito, et al.

• PMID: 39019884

Genome-wide association study on meningioma risk in Japan: a multicenter prospective study

Shuhei Yamada, Toru Umehara, Kyuto Sonehara, et al.

PMID: 39002029

Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population

Ryosuke Fujii, Asahi Hishida, Masahiro Nakatochi, et al.

• PMID: 38961281

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Katherine A. Kentistou, Lena R. Kaisinger, Stasa Stankovic, et al.

• PMID: 38951643

Genome-Wide Association Study with Three Control Cohorts of Japanese Patients with Esotropia and Exotropia of Comitant Strabismus and Idiopathic Superior Oblique Muscle Palsy

Toshihiko Matsuo, Ichiro Hamasaki, Yoichiro Kamatani, et al.

• PMID: 39000095

KEAP1–NRF2 system regulates age-related spermatogenesis dysfunction

Sohei Kuribayashi, Shinichiro Fukuhara, Hiroaki Kitakaze, et al.

• PMID: 38915913

Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, et al.

• PMID: 38910120

Protocol for genome-wide association study of human blood metabolites

Takeshi Iwasaki, Yoichiro Kamatani, Kazuhiro Sonomura, et al.

• PMID: 38700977

RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction

Keiko Hikino, Satoshi Koyama, Kaoru Ito, et al.

• PMID: 38888930

A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk

Bradley Jermy, Kristi Läll, Brooke N. Wolford, et al.

• PMID: 38866767

Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease

Rainer Malik, Nathalie Beaufort, Jiang Li, et al.

• PMID: 39196222

Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses

Takafumi Ojima, Shinichi Namba, Ken Suzuki, et al.

• PMID: 38862855

Genetic variants for head size share genes and pathways with cancer

Maria J. Knol, Raymond A. Poot, Tavia E. Evans, et al.

• PMID: 38703765

Identification of an novel genetic variant associated with osteoporosis: insights from the Taiwan Biobank Study

Yi-Ching Liaw, Koichi Matsuda and Yung-Po Liaw.

• PMID: 38655459

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Zhishan Chen, Xingyi Guo, Ran Tao, et al.

• PMID: 38670944

Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

Mark P. Purdue, Diptavo Dutta, Mitchell J. Machiela, et al.

• PMID: 38671320