Initiatives & Research Initiatives & Research

Initiatives & Research
活動と研究成果

論文成果一覧 -2003年からの論文成果一覧

2024

Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

Mark P. Purdue, Diptavo Dutta, Mitchell J. Machiela, et al.

腎臓がんに関する多祖先集団のゲノムワイド関連解析により、63の感受性領域を特定

2024

Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing

Xiaoxi Liu, Satoshi Koyama, Kohei Tomizuka, et al.

全ゲノム解析で明らかになる日本人の遺伝的起源と特徴

2024

Poor accuracy and sustainability of the first-step FIB4 EASL pathway for stratifying steatotic liver disease risk in the general population

Antonio De Vincentis, Federica Tavaglione, Shinichi Namba, et al.

一般集団における脂肪肝疾患リスクを層別化するための第一段階FIB4 EASL経路の精度と持続可能性の低さ

2024

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, et al.

2型糖尿病の病態生理学における異質性を引き起こす遺伝的要因

2024

GWAS for Systemic Sclerosis Identifies Six Novel Susceptibility Loci Including One in the Fcγ Receptor Region

Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, et al.

全身性強皮症に関するゲノムワイド関連解析により、Fcγ受容体領域を含む6つの新しい感受性遺伝子座を特定

2024

Genetic Architecture of Alcohol Consumption Identified by a Genotype-Stratified GWAS and Impact on Esophageal Cancer Risk in Japanese People

Yuriko N. Koyanagi, Masahiro Nakatochi, Shinichi Namba, et al.

遺伝子型別ゲノムワイド関連解析により特定された飲酒の遺伝的構造と日本人の食道がんリスクへの影響

2024

Multi-Ancestry Genome-Wide Association Study of Major Depression Aids Locus Discovery, Fine Mapping, Gene Prioritization and Causal Inference

Xiangrui Meng, Georgina Navoly, Olga Giannakopoulou, et al.

大うつ病に関する多祖先のゲノムワイド関連解析が遺伝子座の発見、特定、遺伝子の優先順位、原因推定に貢献

2023

Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention

Nicholas A Marston, James P Pirruccello, Giorgio E M Melloni, et al.

2023

Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals

Masato Akiyama, Saori Sakaue, Atsushi Takahashi, et al.

2023

Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction

Kazuo Miyazawa, Kaoru Ito, Masamichi Ito, et al.

2023

Hereditary Cancer Variants and Homologous Recombination Deficiency in Biliary Tract Cancer

Yuki Okawa, Yusuke Iwasaki, Todd A Johnson, et al.

2023

Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer

Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, et al.

2023

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Mark K. Bakker, Jos P. Kanning, Gad Abraham, et al.

2023

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, et al.

2023

Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population

Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, et al.

2023

Genetic footprints of assortative mating in the Japanese population

Kenichi Yamamoto, Kyuto Sonehara, Shinichi Namba, et al.

2023

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

Ying Wang , Shinichi Namba , Esteban Lopera, et al.

2023

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

Yoshihiko Tomofuji, Ken Suzuki, Toshihiro Kishikawa, et al.

2023

Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population

Takuya Sakashita, Yasuyuki Nakamura, Yoichi Sutoh, et al.

2023

Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study

Shogo Dofuku, Kyuto Sonehara, Satoru Miyawaki, et al.

2023

Evidence of Causality of Low Body Mass Index on Risk of Adolescent Idiopathic Scoliosis: A Mendelian Randomization Study

Nao Otomo, Anas M. Khanshour, Masaru Koido, et al.

2023

Prediction Model with HLA-A*33:03 Reveals Number of Days to Develop Liver Cancer from Blood Test

Nao Nishida, Jun Ohashi, Goki Suda, et al.

2023

Genetic Risk of Primary Aldosteronism and its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies

Tatsuhiko Naito, Kosuke Inoue, Kyuto Sonehara, et al.

2023

Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants

Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, et al.

2023

Investigating the Association between Glycaemic Traits and Colorectal Cancer in the Japanese Population using Mendelian Randomisation

Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, et al.

2023

Genome-Wide Association Study of Lung Adenocarcinoma in East Asia and Comparison with a European Population

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, et al.

2023

Mobile Element Variation Contributes to Population-Specific Genome Diversification, Gene Regulation and Disease Risk

Shohei Kojima, Satoshi Koyama, Mirei Ka, et al.

2023

Prediction of the Cell-Type-Specific Transcription of Non-Coding RNAs from Genome Sequences Via Machine Learning

Masaru Koido, Chung-Chau Hon, Satoshi Koyama, et al.

2023

Improved Genetic Prediction of the Risk of Knee Osteoarthritis using the Risk Factor-Based Polygenic Score

Yugo Morita, Yoichiro Kamatani, Hiromu Ito, et al.

2023

Detection of Trait-Associated Structural Variations using Short-Read Sequencing

Shunichi Kosugi, Yoichiro Kamatani, Katsutoshi Harada, et al.

2023

Pan-Cancer and Cross-Population Genome-Wide Association Studies Dissect Shared Genetic Backgrounds Underlying Carcinogenesis

Go Sato, Yuya Shirai, Shinichi Namba, et al.

2023

Genome-Wide Association Study Identifies Risk Loci within the Major Histocompatibility Complex Region for Hunner-Type Interstitial Cystitis

Yoshiyuki Akiyama, Kyuto Sonehara, Daichi Maeda, et al.

2023

GWAS of Folate Metabolism with Gene-Environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese – the J-MICC Study

Mineko Tsukamoto, Asahi Hishida, Takashi Tamura, et al.

2023

Genome-Wide Association Studies Categorized by Class of Antihypertensive Drugs Reveal Complex Pathogenesis of Hypertension with Drug Resistance

Keiko Yamazaki, Chikashi Terao, Atsushi Takahashi, et al.

2023

Hyperfructosemia in Sleep Disordered Breathing: Metabolome Analysis of Nagahama Study

Yoshinari Nakatsuka, Kimihiko Murase, Kazuhiro Sonomura, et al.

2023

A Whole-Genome Reference Panel of 14,393 Individuals for East Asian Populations Accelerates Discovery of Rare Functional Variants

Jaeyong Choi, Sungjae Kim, Juhyun Kim, et al.

2023

Contribution of an Asian-Prevalent HLA Haplotype to the Risk of HBV-Related Hepatocellular Carcinoma

Atsushi Kawamura, Koichi Matsuda, Yoshinori Murakami, et al.

2023

ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk

Lenka Stolarova, Petra Kleiblova, Petra Zemankova, et al.

2023

Androgen Receptor Binding Sites Enabling Genetic Prediction of Mortality due to Prostate Cancer in Cancer-Free Subjects

Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, et al.

2023

GWAS Meta-Analysis of Over 29,000 People with Epilepsy Identifies 26 Risk Loci and Subtype-Specific Genetic Architecture

International League Against Epilepsy Consortium on Complex Epilepsies.

2023

Multi-Ancestry Genome-Wide Analysis Identifies Shared Genetic Effects and Common Genetic Variants for Self-Reported Sleep Duration

B. H. Scammell, C. Tchio, Y. Song, et al.

2023

Boosting the Power of Genome-Wide Association Studies within and Across Ancestries by using Polygenic Scores

Adrian I. Campos, Shinichi Namba, Shu-Chin Lin, et al.

2023

Combining Asian and European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Racial and Ethnic Populations

Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, et al.

2023

Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations

Xiaoxi Liu, Masatoshi Matsunami, Momoko Horikoshi, et al.

2023

Polygenic Prediction Across Populations is Influenced by Ancestry, Genetic Architecture, and Methodology

Ying Wang, Masahiro Kanai, Taotao Tan, et al.

2023

Identification of Telomere Maintenance Gene Variations Related to Lung Adenocarcinoma Risk by Genome-Wide Association and Whole Genome Sequencing Analyses

Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, et al.

2023

A Large-Scale microRNA Transcriptome-Wide Association Study Identifies Two Susceptibility microRNAs, miR-1307-5p and miR-192-3p, for Colorectal Cancer Risk

Zhishan Chen, Weiqiang Lin, Qiuyin Cai, et al.

2023

Extracting Immunological and Clinical Heterogeneity Across Autoimmune Rheumatic Diseases by Cohort-Wide Immunophenotyping

Hiroaki Tanaka, Yukinori Okada, Shingo Nakayamada, et al.

2023

Characterizing Prostate Cancer Risk through Multi-Ancestry Genome-Wide Discovery of 187 Novel Risk Variants

Anqi Wang, Jiayi Shen, Alex A. Rodriguez, et al.

2023

East Asian-Specific and Cross-Ancestry Genome-Wide Meta-Analyses Provide Mechanistic Insights into Peptic Ulcer Disease

Yunye He, Masaru Koido, Yoichi Sutoh, et al.