Research results using research resources of BioBank Japan (BBJ) have been published in Journal of Thoracic Oncology.

A research group led by Kouya Shiraishi, Unit leader at National Cancer Centre Research Institute, investigated the relationship between a polygenic risk score (PRS) for lung adenocarcinoma (LUAD) and mutations in the EGFR gene in 998 East Asian women who never smoked (518 with EGFR-positive LUAD and 480 with EGFR-negative LUAD) along with 4,544 non-smoking controls. Their findings revealed that the PRS was more strongly linked to EGFR-positive LUAD than to EGFR-negative LUAD. Specifically, the highest PRS group had a much higher risk of EGFR-positive LUAD. These results suggest that genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer’s mutation status, which could have significant public health and clinical impacts.

Original paper

Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report
J Thorac Oncol. 2024 Nov 22:S1556-0864(24)02482-1

Press release article from the University of Tokyo (Japanese only)

https://www.ims.u-tokyo.ac.jp/imsut/jp/about/press/page_00310.html