Research results using samples and information from BioBank Japan (BBJ) have been published in the online edition of the international scientific journal Communications Biology.

A joint research team led by Assistant Professor Masatoshi Matsunami at the Graduate School of Medicine, University of the Ryukyus, conducted a genome-wide association studies (GWAS) on pelvic organ prolapse(POP) using DNA from a total of 77,396 individuals, including collaborators from BioBank Japan. The study found that WT1 on chromosome 11 is associated with susceptibility to POP in Japanese women. In addition, an integrated analysis combining the Japanese data and previously reported European data newly identified the locus of FGFR2, as a novel susceptibility locus to POP, on chromosome 10.

For details, please read the original paper and the press release article.

Original paper

Genome-wide association studies for pelvic organ prolapse in the Japanese population
https://www.nature.com/articles/s42003-024-06875-2
Published date: 30 September, 2024

Press release article from University of the Ryukyus (Japanese only)

日本人女性における骨盤臓器脱の遺伝的素因を発見