Research results utilizing the research resources of BioBank Japan (BBJ) have been published in Cell Genomics.

A joint research team led by Assistant Professor Kyuto Sonehara (at the time of the study) and Professor Yukinori Okada of Graduate School of Medicine at the University of Tokyo conducted a genome-wide association studies (GWAS) of vaccine-induced SARS-CoV-2-specific immunoglobulin G (IgG) antibody titers and T cell immune responses in 1,559 mRNA-1273 and 537 BNT162b2 vaccinees of Japanese ancestry. As a result, the team discovered two gene loci (IGH and MHC) involved in immune response to the vaccine. Furthermore, the study revealed that somatic mutations in sex chromosomes reduce immunogenicity and increase susceptibility to infectious diseases and immune disorders.

For further details, please refer to the original paper.

Original Paper

Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity
Cell Genomics, Volume 5, Issue 3, 12 March 2025, 100783