Research results utilizing the bio-resources of BioBank Japan (BBJ) have been published in the international medical journal Blood Cancer Discovery.

A joint research group led by Yoshiaki Usui, Special Postdoctoral Researcher in Basic Sciences at the RIKEN Center for Biomedical Research, and Professor Koichi Matsuda of the Department of Medical Information and Life Sciences, Graduate School of Frontier Sciences, The University of Tokyo, conducted the world’s largest study of clonal haematopoiesis with TP53 mutations to clarify the characteristics and clinical significance, using DNA from 140,597 individuals registered in BioBank Japan (BBJ). A 10-year follow-up analysis revealed that TP53-related clonal haematopoiesis increased the risk of death not only from myeloid and lymphoid tumors (blood cancers), but also from respiratory diseases. The risk was further influenced by specific combinations of genetic and environmental factors.

Original paper

Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases
Blood Cancer Discov. 2025 Jun 17:OF1-OF9

Press release article by RIKEN (Japanese only)

https://www.riken.jp/press/2025/20250617_2/index.html